Design, Synthesis and Biological Activity Testing of Library of Sphk1 Inhibitors

Our team discovered a moderate SphK1 inhibitor, <b>SAMS10</b> (IC₅₀ = 9.8 μM), which was screened by computer-assisted screening. In this study, we developed a series of novel diaryl derivatives with improved antiproliferative activities by modifying the structure of the lead compound <b>...

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Auteurs principaux:	Shuangshuang Geng, Haijiao Chen, Yan Li, Ying Li, Jingxiang Pang, Feipeng Zhang, Zhiqiang Qu, Mengjun Li, Na Liu, Qingqiang Yao, Yanling Mu, Bo Liu
Format:	Artigo
Langue:	Inglês
Publié:	MDPI AG 2022-03-01
Collection:	Molecules
Sujets:	SphK1 inhibitor melanoma PI3K/NF-κB signaling pathway xenograft tumor
Accès en ligne:	https://www.mdpi.com/1420-3049/27/6/2020
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