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Design, Synthesis and Biological Activity Testing of Library of Sphk1 Inhibitors

Our team discovered a moderate SphK1 inhibitor, <b>SAMS10</b> (IC<sub>50</sub> = 9.8 μM), which was screened by computer-assisted screening. In this study, we developed a series of novel diaryl derivatives with improved antiproliferative activities by modifying the structure of the lead compound <b>...

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Principais autores: Shuangshuang Geng, Haijiao Chen, Yan Li, Ying Li, Jingxiang Pang, Feipeng Zhang, Zhiqiang Qu, Mengjun Li, Na Liu, Qingqiang Yao, Yanling Mu, Bo Liu
Format: Artigo
Sprog:Inglês
Udgivet: MDPI AG 2022-03-01
Serier:Molecules
Fag:
SphK1 inhibitor
melanoma
PI3K/NF-κB signaling pathway
xenograft tumor
Online adgang:https://www.mdpi.com/1420-3049/27/6/2020
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