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HIV-1 Vpr suppresses expression of the thiazide-sensitive sodium chloride co-transporter in the distal convoluted tubule

HIV-associated nephropathy (HIVAN) impairs functions of both glomeruli and tubules. Attention has been previously focused on the HIVAN glomerulopathy. Tubular injury has drawn increased attention because sodium wasting is common in hospitalized HIV/AIDS patients. We used viral protein R (Vpr)-transg...

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Huvudupphov: Shashi Shrivastav, Hewang Lee, Koji Okamoto, Huiyan Lu, Teruhiko Yoshida, Khun Zaw Latt, Hidefumi Wakashin, James L. T. Dalgleish, Erik H. Koritzinsky, Peng Xu, Laureano D. Asico, Joon-Yong Chung, Stephen Hewitt, John J. Gildea, Robin A. Felder, Pedro A. Jose, Avi Z. Rosenberg, Mark A. Knepper, Tomoshige Kino, Jeffrey B. Kopp
Materialtyp: Artigo
Språk:Inglês
Utgiven: Public Library of Science (PLoS) 2022-01-01
Serie:PLoS ONE
Länkar:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9491550/?tool=EBI
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