Integrating Population Approaches With Physiologically Based Pharmacokinetic Models: A Novel Framework for Parameter Estimation

ABSTRACT Physiologically Based Pharmacokinetic (PBPK) modeling is a powerful tool in drug development that integrates drug‐specific information with physiological parameters to predict drug concentrations. However, parameter estimation in PBPK models presents significant challenges due to the large...

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Detalles Bibliográficos

Principais autores:	Donato Teutonico, David Marchionni, Marc Lavielle, Laurent Nguyen
Formato:	Artigo
Idioma:	Inglês
Publicado:	Wiley 2026-01-01
Series:	CPT: Pharmacometrics & Systems Pharmacology
Assuntos:	individual variability PBPK physiologically based pharmacokinetics popPBPK popWB‐PBPK SAEM
Acceso en liña:	https://doi.org/10.1002/psp4.70186
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