Host KIR/HLA-C Genotypes Determine HIV-Mediated Changes of the NK Cell Repertoire and Are Associated With Vpu Sequence Variations Impacting Downmodulation of HLA-C

NK cells play a pivotal role in viral immunity, utilizing a large array of activating and inhibitory receptors to identify and eliminate virus-infected cells. Killer-cell immunoglobulin-like receptors (KIRs) represent a highly polymorphic receptor family, regulating NK cell activity and determining...

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Autori principali:	Sarah Vollmers, Annabelle Lobermeyer, Annika Niehrs, Pia Fittje, Daniela Indenbirken, Jacqueline Nakel, Sanamjeet Virdi, Sebastien Brias, Timo Trenkner, Gabriel Sauer, Sven Peine, Georg M.N. Behrens, Clara Lehmann, Anja Meurer, Ramona Pauli, Nils Postel, Julia Roider, Stefan Scholten, Christoph D. Spinner, Christoph Stephan, Eva Wolf, Christoph Wyen, Laura Richert, Paul J. Norman, Jürgen Sauter, Alexander H. Schmidt, Angelique Hoelzemer, Marcus Altfeld, Christian Körner
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Frontiers Media S.A. 2022-07-01
Serie:	Frontiers in Immunology
Soggetti:	NK cell KIR HLA-C HIV-1 Vpu
Accesso online:	https://www.frontiersin.org/articles/10.3389/fimmu.2022.922252/full
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