Co-expression of HLA-E and HLA-G on genetically modified porcine endothelial cells attenuates human NK cell-mediated degranulation

Natural killer (NK) cells play an important role in immune rejection in solid organ transplantation. To mitigate human NK cell activation in xenotransplantation, introducing inhibitory ligands on xenografts via genetic engineering of pigs may protect the graft from human NK cell-mediated cytotoxicit...

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Prif Awduron:	Arthur A. Cross-Najafi, Kristine Farag, Abdulkadir Isidan, Wei Li, Wenjun Zhang, Zhansong Lin, Julia R. Walsh, Kevin Lopez, Yujin Park, Nancy G. Higgins, David K.C. Cooper, Burcin Ekser, Ping Li
Fformat:	Artigo
Iaith:	Inglês
Cyhoeddwyd:	Frontiers Media S.A. 2023-07-01
Cyfres:	Frontiers in Immunology
Pynciau:	xenotransplantation natural killer cells immune tolerance immune rejection HLA-E HLA-G
Mynediad Ar-lein:	https://www.frontiersin.org/articles/10.3389/fimmu.2023.1217809/full
Tagiau:	Ychwanegu Tag Dim Tagiau, Byddwch y cyntaf i dagio'r cofnod hwn!