Letermovir does not affect long-term polyclonal immune reconstitution after allogeneic hematopoietic stem cell transplantation with ATG-based GvHD prophylaxis

IntroductionLetermovir (LET) is an effective prophylaxis for human cytomegalovirus (HCMV) reactivations in HCMV-seropositive patients after allogeneic stem cell transplantation (allo-SCT). HCMV promotes polyfunctional T-cell responses, leading to HCMV-specific immune reconstitution (IR), thus contri...

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Autori principali:	Conrad Weidt, Adela Maria Neagoie, Maral Saadati, Daniel Fürst, Verena Wais, Christian Sinzger, Katrin Strauss, Katharina Göhring, Jacqueline Schnell, Michaela Feuring, Frank Stegelmann, Axel Benner, Detlef Michel, Thomas Stamminger, Hartmut Döhner, Donald Bunjes, Elisa Sala
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Frontiers Media S.A. 2026-05-01
Serie:	Frontiers in Immunology
Soggetti:	allogeneic stem cell transplantation human cytomegalovirus immune reconstitution letermovir pre-emptive treatment
Accesso online:	https://www.frontiersin.org/articles/10.3389/fimmu.2026.1790563/full
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