Inhibition of CD38 enzyme activity on engrafted human immune cells enhances NAD+ metabolism and inhibits inflammation in an in-vivo model of xeno-GvHD

IntroductionCD38 is highly expressed on immune cells. It catabolizes NAD+, which is a critical cofactor for enzymes involved in metabolism and energy production. Methods and resultsWe developed TNB-738, a fully human antibody that potently inhibits human CD38 enzymatic activity on human immune cells...

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Bibliografiska uppgifter

Huvudupphov:	Ghenima Ahmil-Boiteau, Pranjali Dalvi, Kevin Dang, Harshad S. Ugamraj, Giulia Castello, James Allison, Ute Schellenberger, Roland Buelow, Suhasini Iyer, Ben Buelow, Eduardo Chini, Bruce Blazar, Maria Cristina Cuturi, Wim van Schooten, Laure-Hélène Ouisse
Materialtyp:	Artigo
Språk:	Inglês
Utgiven:	Frontiers Media S.A. 2025-10-01
Serie:	Frontiers in Immunology
Ämnen:	CD38 GvHD NAD+ inflammation TNB-738
Länkar:	https://www.frontiersin.org/articles/10.3389/fimmu.2025.1640611/full
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