Discovery of Cofactor Competitive Inhibitors against the Human Methyltransferase Fibrillarin

Fibrillarin (FBL) is an essential and evolutionarily highly conserved S-adenosyl methionine (SAM) dependent methyltransferase. It is the catalytic component of a multiprotein complex that facilitates 2′-<i>O</i>-methylation of ribosomal RNAs (rRNAs), a modification essential for accurate and efficie...

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Principais autores:	Yun Shi, Ibrahim M. El-Deeb, Veronika Masic, Lauren Hartley-Tassell, Andrea Maggioni, Mark von Itzstein, Thomas Ve
Formato:	Artigo
Idioma:	Inglês
Publicado:	MDPI AG 2021-12-01
Series:	Pharmaceuticals
Assuntos:	methyltransferase S-adenosyl methionine cofactor fragment screening inhibitors
Acceso en liña:	https://www.mdpi.com/1424-8247/15/1/26
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