Structural insights into proprotein convertase activation facilitate the engineering of highly specific furin inhibitors

Abstract Proprotein convertases (PCs), including furin and PC1/3 among nine mammalian homologues, mediate the maturation of numerous secreted substrates by proteolytic cleavage. Disbalance of PC activity is associated with diseases like cancer, fibrosis, neurodegeneration and infections. Therefore,...

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Váldodahkkit:	Rupert Klaushofer, Konstantin Bloch, Luisa Susanna Eder, Simone Marzaro, Mario Schubert, Eva Böttcher-Friebertshäuser, Hans Brandstetter, Sven O. Dahms
Materiálatiipa:	Artigo
Giella:	Inglês
Almmustuhtton:	Nature Portfolio 2025-09-01
Ráidu:	Nature Communications
Liŋkkat:	https://doi.org/10.1038/s41467-025-63479-y
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