Oncolytic virus hijacks GOT1 and pyrimidinosomes to fuel pyrimidine synthesis for replication in tumor cells

Oncolytic viruses selectively infect and kill tumor cells, but the metabolic adaptations that support their replication remain incompletely understood. Here, using oncolytic Newcastle disease virus (NDV) as a model, we identify glutamic-oxaloacetic transaminase 1 (GOT1) as a key metabolic enzyme req...

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Autors principals:	Ning Tang, Yabin Gong, Changrun Zhao, Yujia Niu, Lei Tan, Cuiping Song, Xusheng Qiu, Ying Liao, Shengqing Yu, Chan Ding, Shuhai Lin, Yingjie Sun
Format:	Artigo
Idioma:	Inglês
Publicat:	Elsevier 2026-06-01
Col·lecció:	Tumour Virus Research
Matèries:	Oncolytic newcastle disease virus Pyrimidinosome Pyrimidine synthesis GOT1 CAD NAD+/NADH
Accés en línia:	http://www.sciencedirect.com/science/article/pii/S2666679026000066
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