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Oncolytic virus hijacks GOT1 and pyrimidinosomes to fuel pyrimidine synthesis for replication in tumor cells

Oncolytic viruses selectively infect and kill tumor cells, but the metabolic adaptations that support their replication remain incompletely understood. Here, using oncolytic Newcastle disease virus (NDV) as a model, we identify glutamic-oxaloacetic transaminase 1 (GOT1) as a key metabolic enzyme req...

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Hlavní autoři: Ning Tang, Yabin Gong, Changrun Zhao, Yujia Niu, Lei Tan, Cuiping Song, Xusheng Qiu, Ying Liao, Shengqing Yu, Chan Ding, Shuhai Lin, Yingjie Sun
Médium: Artigo
Jazyk:Inglês
Vydáno: Elsevier 2026-06-01
Edice:Tumour Virus Research
Témata:
Oncolytic newcastle disease virus
Pyrimidinosome
Pyrimidine synthesis
GOT1
CAD
NAD+/NADH
On-line přístup:http://www.sciencedirect.com/science/article/pii/S2666679026000066
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