Discovery of novel potential small-molecule inhibitors of MMP-9 based on a pharmacophore virtual screening strategy
Background: Matrix metalloproteinases (MMPs) are a class of calcium-dependent, zinc-containing endopeptidases involved in several cellular processes. MMP-9, among MMP isoforms, drives tumor invasion, rheumatoid arthritis, and osteoarthritis via extracellular matrix degradation in the tumor microenvi...
Guardat en:
| Autors principals: | , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
Elsevier
2025-05-01
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| Col·lecció: | Results in Chemistry |
| Matèries: | |
| Accés en línia: | http://www.sciencedirect.com/science/article/pii/S2211715625002760 |
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