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Discovery of novel potential small-molecule inhibitors of MMP-9 based on a pharmacophore virtual screening strategy

Background: Matrix metalloproteinases (MMPs) are a class of calcium-dependent, zinc-containing endopeptidases involved in several cellular processes. MMP-9, among MMP isoforms, drives tumor invasion, rheumatoid arthritis, and osteoarthritis via extracellular matrix degradation in the tumor microenvi...

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Bibliografische gegevens
Hoofdauteurs: Yi Wang, Xuekun Shao, Ping Wang
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Elsevier 2025-05-01
Reeks:Results in Chemistry
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Online toegang:http://www.sciencedirect.com/science/article/pii/S2211715625002760
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