Discovery of novel potential small-molecule inhibitors of MMP-9 based on a pharmacophore virtual screening strategy
Background: Matrix metalloproteinases (MMPs) are a class of calcium-dependent, zinc-containing endopeptidases involved in several cellular processes. MMP-9, among MMP isoforms, drives tumor invasion, rheumatoid arthritis, and osteoarthritis via extracellular matrix degradation in the tumor microenvi...
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| Hoofdauteurs: | , , |
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| Formaat: | Artigo |
| Taal: | Inglês |
| Gepubliceerd in: |
Elsevier
2025-05-01
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| Reeks: | Results in Chemistry |
| Onderwerpen: | |
| Online toegang: | http://www.sciencedirect.com/science/article/pii/S2211715625002760 |
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