Trans-Golgi network tethering factors regulate TBK1 trafficking and promote the STING-IFN-I pathway

Abstract The cGAS-STING pathway mediates the innate immune response to cytosolic DNA, contributing to surveillance against microbial invasion or cellular damage. Once activated, STING recruits TBK1 at the trans-Golgi network (TGN), which in turn phosphorylates IRF3 to induce type I interferon (IFN-I...

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Principais autores:	Jinrui Wang, Shenghui Niu, Xiao Hu, Tianxing Li, Shengduo Liu, Yingfeng Tu, Zehua Shang, Lin Zhao, Pinglong Xu, Jingwen Lin, Lu Chen, Daniel D. Billadeau, Da Jia
Formato:	Artigo
Idioma:	Inglês
Publicado:	Nature Publishing Group 2025-03-01
Series:	Cell Discovery
Acceso en liña:	https://doi.org/10.1038/s41421-024-00763-z
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