Trans-Golgi network tethering factors regulate TBK1 trafficking and promote the STING-IFN-I pathway
Abstract The cGAS-STING pathway mediates the innate immune response to cytosolic DNA, contributing to surveillance against microbial invasion or cellular damage. Once activated, STING recruits TBK1 at the trans-Golgi network (TGN), which in turn phosphorylates IRF3 to induce type I interferon (IFN-I...
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| Hlavní autoři: | , , , , , , , , , , , , |
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| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
Nature Publishing Group
2025-03-01
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| Edice: | Cell Discovery |
| On-line přístup: | https://doi.org/10.1038/s41421-024-00763-z |
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