AMPK-dependent maturation of hiPSC-derived cardiomyocytes induced by human cardiac fibroblast exosomes

Background Human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) are a promising therapy for ischemic cardiomyopathy, which is often secondary to hypertension but remain functionally immature. We investigated whether exosomes from human cardiac fibroblasts (hc-FB-EXOs) promote hiPSC...

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Detalhes bibliográficos

Principais autores:	Kele Qin, Xiuneng Li, Xun Wu, Xiaohui Xie, Kun Xiang, Huatao Zhou, Jinfu Yang, Chengming Fan
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Taylor & Francis Group 2026-12-01
coleção:	Clinical and Experimental Hypertension
Assuntos:	Human induced-pluripotent stem cell derived cardiomyocytes cardiac fibroblast exosome maturation AMPK
Acesso em linha:	https://www.tandfonline.com/doi/10.1080/10641963.2026.2631601
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