IL-6 signaling blockade increases inflammation but does not affect muscle function in the <it>mdx</it> mouse

<p>Abstract</p> <p>Background</p> <p>IL-6 is a pleiotropic cytokine that modulates inflammatory responses and plays critical roles in muscle maintenance and remodeling. In the mouse model (<it>mdx</it>) of Duchenne Muscular Dystrophy, IL-6 and muscle inflammation are elevated, which is believed to c...

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書誌詳細

主要な著者:	Kostek Matthew C, Nagaraju Kanneboyina, Pistilli Emidio, Sali Arpana, Lai San-Huei, Gordon Brad, Chen Yi-Wen
フォーマット:	Artigo
言語:	Inglês
出版事項:	BMC 2012-06-01
シリーズ:	BMC Musculoskeletal Disorders
主題:	IL-6 Muscular dystrophy Inflammation Duchenne
オンライン･アクセス:	http://www.biomedcentral.com/1471-2474/13/106
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