Mitochondrial Dysfunction Is an Early Consequence of Partial or Complete Dystrophin Loss in mdx Mice

Duchenne muscular dystrophy (DMD) is characterized by rapid wasting of skeletal muscle. Mitochondrial dysfunction is a well-known pathological feature of DMD. However, whether mitochondrial dysfunction occurs before muscle fiber damage in DMD pathology is not well known. Furthermore, the impact upon...

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Principais autores:	Timothy M. Moore, Amanda J. Lin, Alexander R. Strumwasser, Kevin Cory, Kate Whitney, Theodore Ho, Timothy Ho, Joseph L. Lee, Daniel H. Rucker, Christina Q. Nguyen, Aidan Yackly, Sushil K. Mahata, Jonathan Wanagat, Linsey Stiles, Lorraine P. Turcotte, Rachelle H. Crosbie, Zhenqi Zhou
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Frontiers Media S.A. 2020-06-01
coleção:	Frontiers in Physiology
Assuntos:	muscular dystrophy Duchenne muscular dystrophy skeletal muscle dystrophin metabolism mitochondria
Acesso em linha:	https://www.frontiersin.org/article/10.3389/fphys.2020.00690/full
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