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Aggregates Associated with Instability of Antibodies during Aerosolization Induce Adverse Immunological Effects

Background: Immunogenicity refers to the inherent ability of a molecule to stimulate an immune response. Aggregates are one of the major risk factors for the undesired immunogenicity of therapeutic antibodies (Ab) and may ultimately result in immune-mediated adverse effects. For Ab delivered by inha...

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Autori principali: Thomas Sécher, Elsa Bodier-Montagutelli, Christelle Parent, Laura Bouvart, Mélanie Cortes, Marion Ferreira, Ronan MacLoughlin, Guy Ilango, Otmar Schmid, Renaud Respaud, Nathalie Heuzé-Vourc’h
Natura: Artigo
Lingua:Inglês
Pubblicazione: MDPI AG 2022-03-01
Serie:Pharmaceutics
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Accesso online:https://www.mdpi.com/1999-4923/14/3/671
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