Quantitative deviations arising from internal standards other than stable-isotope-labeled internal standards in LC–MS/MS

Liquid chromatography–tandem mass spectrometry is widely recognized as a useful tool for analyzing trace components in biological samples; however, it is prone to interference from the sample matrix (matrix effect, ME). A common solution is to use stable-isotope-labeled internal standards (SIL-ISs)....

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Autores principales:	Mayuko Oka, Shion Miyoshi, Takuma Isshiki
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	Elsevier 2026-08-01
Colección:	Talanta Open
Materias:	LC-ESI-MS/MS Amino acids Validation Matrix effect Hydrophilic interaction liquid chromatography
Acceso en línea:	http://www.sciencedirect.com/science/article/pii/S2666831926000305
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