Computational discovery of BRD4 inhibitors for neuroblastoma therapy using pharmacophore screening and molecular simulations

Abstract BRD4 (“Bromodomain-containing protein 4”), a recognized gene regulator, is an attractive target for therapeutic development, particularly for the management of neuroblastoma. An integrated pharmacoinformatic strategy for the development of new BRD4 inhibitors is examined in this research. P...

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Номзүйн дэлгэрэнгүй

Үндсэн зохиолчид:	Iqra Ali, Mervt Almostafa, Faheem Abbas, Nancy S. Younis, Azmat Ali Khan, Galal Yahya
Формат:	Artigo
Хэл сонгох:	Inglês
Хэвлэсэн:	Nature Portfolio 2025-10-01
Цуврал:	Scientific Reports
Нөхцлүүд:	Bromodomain-containing protein 4 Pharmacoinformatic approach Virtual screening ADMET Molecular dynamics (MD) simulation
Онлайн хандалт:	https://doi.org/10.1038/s41598-025-20714-2
Шошгууд:	Шошго нэмэх Шошго байхгүй, Энэхүү баримтыг шошголох эхний хүн болох!