One Pot Synthesis of Micromolar BACE-1 Inhibitors Based on the Dihydropyrimidinone Scaffold and Their Thia and Imino Analogues

A library of dihydropyrimidinones was synthesized via a “one-pot” three component Biginelli reaction using different aldehydes in combination with β-dicarbonyl compounds and urea. Selected 2-thiooxo and 2-imino analogs were also obtained with the Biginelli reaction from thiourea and guanidine hydroc...

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Hauptverfasser:	Jessica Bais, Fabio Benedetti, Federico Berti, Iole Cerminara, Sara Drioli, Maria Funicello, Giorgia Regini, Mattia Vidali, Fulvia Felluga
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	MDPI AG 2020-09-01
Schriftenreihe:	Molecules
Schlagworte:	Alzheimer’s disease dihydropyrimidinones Biginelli reaction β-secretase BACE-1 inhibitors
Online-Zugang:	https://www.mdpi.com/1420-3049/25/18/4152
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