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Identification of galectin-1 and other cellular targets of alpha,beta-unsaturated carbonyl compounds, including dimethylfumarate, by use of click-chemistry probes

α,β-Unsaturated carbonyls are a common motif in environmental toxins (e.g. acrolein) as well as therapeutic drugs, including dimethylfumarate (DMFU) and monomethylfumarate (MMFU), which are used to treat multiple sclerosis and psoriasis. These compounds form adducts with protein Cys residues as well...

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Uloženo v:
Hlavní autoři: Max B. Sauerland, Christina Helm, Lasse G. Lorentzen, Asmita Manandhar, Trond Ulven, Luke F. Gamon, Michael J. Davies
Médium: Artigo
Jazyk:Inglês
Vydáno: Elsevier 2023-02-01
Edice:Redox Biology
Témata:
Dimethylfumarate
Unsaturated carbonyls
Michael adduct
Click chemistry
Galectin
Electrophile
On-line přístup:http://www.sciencedirect.com/science/article/pii/S2213231722003329
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