Identification of galectin-1 and other cellular targets of alpha,beta-unsaturated carbonyl compounds, including dimethylfumarate, by use of click-chemistry probes

α,β-Unsaturated carbonyls are a common motif in environmental toxins (e.g. acrolein) as well as therapeutic drugs, including dimethylfumarate (DMFU) and monomethylfumarate (MMFU), which are used to treat multiple sclerosis and psoriasis. These compounds form adducts with protein Cys residues as well...

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Auteurs principaux:	Max B. Sauerland, Christina Helm, Lasse G. Lorentzen, Asmita Manandhar, Trond Ulven, Luke F. Gamon, Michael J. Davies
Format:	Artigo
Langue:	Inglês
Publié:	Elsevier 2023-02-01
Collection:	Redox Biology
Sujets:	Dimethylfumarate Unsaturated carbonyls Michael adduct Click chemistry Galectin Electrophile
Accès en ligne:	http://www.sciencedirect.com/science/article/pii/S2213231722003329
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