Improving the production of 9α-hydroxy-4-androstene-3,17-dione from phytosterols by 3-ketosteroid-Δ1-dehydrogenase deletions and multiple genetic modifications in Mycobacterium fortuitum

Abstract Background 9α-hydroxyandrost-4-ene-3,17-dione (9-OHAD) is a significant intermediate for the synthesis of glucocorticoid drugs. However, in the process of phytosterol biotransformation to manufacture 9-OHAD, product degradation, and by-products restrict 9-OHAD output. In this study, to cons...

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Bibliografski detalji

Glavni autori:	Xiangcen Liu, Jingxian Zhang, Chenyang Yuan, Guilin Du, Suwan Han, Jiping Shi, Junsong Sun, Baoguo Zhang
Format:	Artigo
Jezik:	Inglês
Izdano:	BMC 2023-03-01
Serija:	Microbial Cell Factories
Teme:	9α-hydroxy-4-androstene-3,17-dione Phytosterol 3-ketosteroid-∆1-dehydrogenase Mycobacterium fortuitum
Online pristup:	https://doi.org/10.1186/s12934-023-02052-y
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