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Pseudorabies virus tegument protein pUL49 antagonizes cyclic GMP-AMP synthase through phase separation to promote viral replication

Pseudorabies virus (PRV) is an economically important swine alphaherpesvirus with zoonotic potential. The mechanisms underlying PRV innate immune evasion remain poorly understood. Here, we identify the PRV tegument protein pUL49 as a critical viral factor that undergoes phase separation to antagoniz...

Ausführliche Beschreibung

Gespeichert in:
Hauptverfasser: Lipeng Gan, Yuan Gao, Lina Ma, Yutong Zhang, Shiyi Chai, Huiying Li, Mengting Zhang, Xinya Yang, Qingcui Xiao, Yinli Xie, Longwei Zhao, Peng Sun, Zhiyong Li
Format: Artigo
Sprache:Inglês
Veröffentlicht: Frontiers Media S.A. 2026-07-01
Schriftenreihe:Frontiers in Microbiology
Schlagworte:
cGAS
phase separation
pseudorabies virus
pUL49
viral replication
Online-Zugang:https://www.frontiersin.org/articles/10.3389/fmicb.2026.1873742/full
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