Pseudorabies virus tegument protein pUL49 antagonizes cyclic GMP-AMP synthase through phase separation to promote viral replication

Pseudorabies virus (PRV) is an economically important swine alphaherpesvirus with zoonotic potential. The mechanisms underlying PRV innate immune evasion remain poorly understood. Here, we identify the PRV tegument protein pUL49 as a critical viral factor that undergoes phase separation to antagoniz...

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Váldodahkkit:	Lipeng Gan, Yuan Gao, Lina Ma, Yutong Zhang, Shiyi Chai, Huiying Li, Mengting Zhang, Xinya Yang, Qingcui Xiao, Yinli Xie, Longwei Zhao, Peng Sun, Zhiyong Li
Materiálatiipa:	Artigo
Giella:	Inglês
Almmustuhtton:	Frontiers Media S.A. 2026-07-01
Ráidu:	Frontiers in Microbiology
Fáttát:	cGAS phase separation pseudorabies virus pUL49 viral replication
Liŋkkat:	https://www.frontiersin.org/articles/10.3389/fmicb.2026.1873742/full
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