Danthron as a novel IL-6R agonist promotes thrombopoiesis via the SRC/RAS/MAPK pathway

BackgroundThis study aimed to investigate the effects of danthron on promoting megakaryocyte (MK) differentiation and alleviating thrombocytopenia, as well as to elucidate its underlying mechanisms.MethodsCell proliferation and apoptosis of Meg-01 and K562 cells were evaluated by CCK-8, LDH release,...

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Detalhes bibliográficos

Principais autores:	Rui Liao, Jiesi Luo, Xiaoxuan Li, Xiaoqin Tang, Miao Huang, Ling Zhou, Long Yun, Zhixuan Liu, Peilian Jiang, Xinle Wang, Xiaolin Gan, Long Wang, Jianming Wu
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Frontiers Media S.A. 2026-03-01
coleção:	Frontiers in Immunology
Assuntos:	danthron IL-6R megakaryocyte platelet SRC/RAS/MAPK thrombocytopenia
Acesso em linha:	https://www.frontiersin.org/articles/10.3389/fimmu.2026.1730028/full
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