Danthron as a novel IL-6R agonist promotes thrombopoiesis via the SRC/RAS/MAPK pathway

BackgroundThis study aimed to investigate the effects of danthron on promoting megakaryocyte (MK) differentiation and alleviating thrombocytopenia, as well as to elucidate its underlying mechanisms.MethodsCell proliferation and apoptosis of Meg-01 and K562 cells were evaluated by CCK-8, LDH release,...

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Главные авторы:	Rui Liao, Jiesi Luo, Xiaoxuan Li, Xiaoqin Tang, Miao Huang, Ling Zhou, Long Yun, Zhixuan Liu, Peilian Jiang, Xinle Wang, Xiaolin Gan, Long Wang, Jianming Wu
Формат:	Artigo
Язык:	Inglês
Опубликовано:	Frontiers Media S.A. 2026-03-01
Серии:	Frontiers in Immunology
Предметы:	danthron IL-6R megakaryocyte platelet SRC/RAS/MAPK thrombocytopenia
Online-ссылка:	https://www.frontiersin.org/articles/10.3389/fimmu.2026.1730028/full
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