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Haploinsufficiency of Endothelial Nitric Oxide Synthase Mitigates Beneficial Effects of Maternal Exercise on Fetal Heart Development During Pregestational Diabetes

Background Pregestational diabetes (PGD) increases congenital heart defect (CHD) risk over 5‐fold. Maternal exercise enhances eNOS (endothelial nitric oxide synthase) activity, benefiting embryos, though its causal role remains unclear. This study investigated the role of eNOS in maternal exercise‐m...

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Principais autores: Ryleigh Van Neck, Xiangru Lu, Thomas Pan, Ivana Du, Lambertus J. Wisse, Marco C. DeRuiter, Qingping Feng
Format: Artigo
Sprog:Inglês
Udgivet: Wiley 2026-01-01
Serier:Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Fag:
congenital heart defects
embryonic heart development
endothelial nitric oxide synthase
maternal exercise
oxidative stress
pregestational diabetes
Online adgang:https://www.ahajournals.org/doi/10.1161/JAHA.125.042848
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