Haploinsufficiency of Endothelial Nitric Oxide Synthase Mitigates Beneficial Effects of Maternal Exercise on Fetal Heart Development During Pregestational Diabetes

Background Pregestational diabetes (PGD) increases congenital heart defect (CHD) risk over 5‐fold. Maternal exercise enhances eNOS (endothelial nitric oxide synthase) activity, benefiting embryos, though its causal role remains unclear. This study investigated the role of eNOS in maternal exercise‐m...

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Auteurs principaux:	Ryleigh Van Neck, Xiangru Lu, Thomas Pan, Ivana Du, Lambertus J. Wisse, Marco C. DeRuiter, Qingping Feng
Format:	Artigo
Langue:	Inglês
Publié:	Wiley 2026-01-01
Collection:	Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Sujets:	congenital heart defects embryonic heart development endothelial nitric oxide synthase maternal exercise oxidative stress pregestational diabetes
Accès en ligne:	https://www.ahajournals.org/doi/10.1161/JAHA.125.042848
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