QR Code

Regulated IRE1α-dependent decay (RIDD)-mediated reprograming of lipid metabolism in cancer

IRE1α cleaves several mRNAs upon accumulation of misfolded proteins. Here the authors show that active IRE1α cleaves DGAT2 mRNA encoding the rate-limiting enzyme in the synthesis of triacylglycerols, suggesting a role of IRE1α in reprogramming lipid metabolism in cancer cells.

Saved in:
Main Authors: Aitor Almanza, Katarzyna Mnich, Arnaud Blomme, Claire M. Robinson, Giovanny Rodriguez-Blanco, Sylwia Kierszniowska, Eoghan P. McGrath, Matthieu Le Gallo, Eleftherios Pilalis, Johannes V. Swinnen, Aristotelis Chatziioannou, Eric Chevet, Adrienne M. Gorman, Afshin Samali
Format: Artigo
Language:Inglês
Published: Nature Portfolio 2022-05-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-022-30159-0
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items