Regulated IRE1α-dependent decay (RIDD)-mediated reprograming of lipid metabolism in cancer
IRE1α cleaves several mRNAs upon accumulation of misfolded proteins. Here the authors show that active IRE1α cleaves DGAT2 mRNA encoding the rate-limiting enzyme in the synthesis of triacylglycerols, suggesting a role of IRE1α in reprogramming lipid metabolism in cancer cells.
Enregistré dans:
| Auteurs principaux: | , , , , , , , , , , , , , |
|---|---|
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
Nature Portfolio
2022-05-01
|
| Collection: | Nature Communications |
| Accès en ligne: | https://doi.org/10.1038/s41467-022-30159-0 |
| Tags: |
Pas de tags, Soyez le premier à ajouter un tag!
|