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γδ T cell receptor recognition of CD1d in a lipid-independent manner

Abstract The monomorphic antigen-presenting molecule CD1d presents lipid antigens to both αβ and γδ T cells. While type I natural killer T cells (NKT) display exquisite specificity for CD1d presenting α-galactosylceramide (α-GalCer), the extent of lipid specificity exhibited by CD1d-restricted γδ T...

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Autori principali: Michael T. Rice, Sachith D. Gunasinghe, Chhon Ling Sok, Mengqi Pan, Chan-Sien Lay, Benjamin S. Gully, Jamie Rossjohn
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Portfolio 2025-12-01
Serie:Nature Communications
Accesso online:https://doi.org/10.1038/s41467-025-67653-0
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