Neuron loss and degeneration in the progression of TDP-43 in frontotemporal lobar degeneration

Abstract Frontotemporal lobar degeneration with TDP-43 inclusions (FTLD-TDP) is associated with the accumulation of pathological neuronal and glial intracytoplasmic inclusions as well as accompanying neuron loss. We explored if cortical neurons detected by NeuN decreased with increasing TDP-43 inclu...

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Autors principals:	Ahmed Yousef, John L. Robinson, David J. Irwin, Matthew D. Byrne, Linda K. Kwong, Edward B. Lee, Yan Xu, Sharon X. Xie, Lior Rennert, EunRan Suh, Vivianna M. Van Deerlin, Murray Grossman, Virginia M.-Y. Lee, John Q. Trojanowski
Format:	Artigo
Idioma:	Inglês
Publicat:	BMC 2017-09-01
Col·lecció:	Acta Neuropathologica Communications
Matèries:	TDP-43 C9orf72 GRN Frontotemporal lobar degeneration NeuN Neurodegeneration
Accés en línia:	http://link.springer.com/article/10.1186/s40478-017-0471-3
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