Serum total TDP-43 levels are decreased in frontotemporal dementia patients with C9orf72 repeat expansion or concomitant motoneuron disease phenotype

Abstract Background Frontotemporal dementia (FTD) covers a spectrum of neurodegenerative disorders with various clinical and neuropathological subtypes. The two major pathological proteins accumulating in the brains of FTD patients, depending on their genetic background, are TDP-43 and tau. We aimed...

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Principais autores:	Kasper Katisko, Nadine Huber, Tarja Kokkola, Päivi Hartikainen, Johanna Krüger, Anna-Leena Heikkinen, Veera Paananen, Ville Leinonen, Ville E. Korhonen, Seppo Helisalmi, Sanna-Kaisa Herukka, Valentina Cantoni, Yasmine Gadola, Silvana Archetti, Anne M. Remes, Annakaisa Haapasalo, Barbara Borroni, Eino Solje
Formato:	Artigo
Idioma:	Inglês
Publicado:	BMC 2022-10-01
Series:	Alzheimer’s Research & Therapy
Assuntos:	Frontotemporal dementia Frontotemporal lobar degeneration TDP-43 proteinopathy C9orf72 GRN Diagnostics
Acceso en liña:	https://doi.org/10.1186/s13195-022-01091-8
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