Targeting tumor-infiltrating CCR8+ regulatory T cells induces antitumor immunity through functional restoration of CD4+ Tconvs and CD8+ T cells in colorectal cancer

Abstract Background Chemokine (C-C motif) receptor 8 (CCR8) is a chemokine receptor selectively expressed on tumor-infiltrating regulatory T cells (Tregs). Strong immunosuppression mediated by CCR8+ Tregs observed in breast and lung malignancies suggest for their functional significance in cancer th...

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Hlavní autoři:	Qian Chen, Meiying Shen, Min Yan, Xiaojian Han, Song Mu, Ya Li, Luo Li, Yingming Wang, Shenglong Li, Tingting Li, Yingying Wang, Wang Wang, Zhengqiang Wei, Chao Hu, Aishun Jin
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	BMC 2024-07-01
Edice:	Journal of Translational Medicine
Témata:	Colorectal cancer (CRC) Regulatory T cell (Treg) Chemokine (C-C motif) receptor 8 (CCR8)
On-line přístup:	https://doi.org/10.1186/s12967-024-05518-8
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