Single-cell transcriptomics unravels the early immune landscape of renal allograft rejection and nominates Ccl3-Ccr5 as a therapeutic target

BackgroundAcute rejection is a significant cause of impaired graft survival in the early post-transplantation period, and the early-stage immune cell dynamics with local intercellular communication during this process require further elucidation.MethodsWe performed single-cell RNA sequencing (scRNA-...

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Váldodahkkit:	Fanchao Wei, Zhaoxiang Wang, Ruochen Qi, Jingliang Zhang, Shichao Han, Changhong Shi, Tong Lu, Zhite Zhao, Zhengxuan Li, Lang Li, Weijun Qin, Shuaijun Ma, Lijun Yang
Materiálatiipa:	Artigo
Giella:	Inglês
Almmustuhtton:	Frontiers Media S.A. 2025-10-01
Ráidu:	Frontiers in Immunology
Fáttát:	kidney transplant acute rejection macrophages ScRNA-seq Cc3-Ccr5
Liŋkkat:	https://www.frontiersin.org/articles/10.3389/fimmu.2025.1663251/full
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