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Single-cell transcriptomics unravels the early immune landscape of renal allograft rejection and nominates Ccl3-Ccr5 as a therapeutic target

BackgroundAcute rejection is a significant cause of impaired graft survival in the early post-transplantation period, and the early-stage immune cell dynamics with local intercellular communication during this process require further elucidation.MethodsWe performed single-cell RNA sequencing (scRNA-...

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Principais autores: Fanchao Wei, Zhaoxiang Wang, Ruochen Qi, Jingliang Zhang, Shichao Han, Changhong Shi, Tong Lu, Zhite Zhao, Zhengxuan Li, Lang Li, Weijun Qin, Shuaijun Ma, Lijun Yang
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2025-10-01
Serier:Frontiers in Immunology
Fag:
kidney transplant
acute rejection
macrophages
ScRNA-seq
Cc3-Ccr5
Online adgang:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1663251/full
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