Mendelian Randomization and Bayesian Colocalization Analysis Implicate Glycoprotein VI as a Potential Drug Target for Cardioembolic Stroke in South Asian Populations

Background Circulating plasma proteins are clinically useful biomarkers for stroke risk. We examined the causal links between plasma proteins and stroke risk in individuals of South Asian ancestry. Methods and Results We applied proteome‐wide Mendelian randomization and colocalization approaches to...

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Principais autores:	Siwei Wu, Devendra Meena, James Yarmolinsky, Dipender Gill, Alexander Smith, Marie‐Joe Dib, Ganesh Chauhan, Anand Rohatgi, Abbas Dehghan, Ioanna Tzoulaki
Format:	Artigo
Jezik:	Inglês
Izdano:	Wiley 2024-08-01
Serija:	Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Teme:	cardioembolic GP6 Mendelian randomization South Asian ancestry stroke
Online dostop:	https://www.ahajournals.org/doi/10.1161/JAHA.124.035008
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