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Improved Intestinal Permeation of Cyclosporin a by FCIGRL-Modified Tight Junction Modulator in Rats

<b>Objectives:</b> Cyclosporin A (CsA) is an immunosuppressive drug that is highly effective. CsA, similar to other drugs with limited oral bioavailability due to poor membrane permeability, requires the use of absorption enhancers in its formulations. Phe-Cys-Ile-Gly-Arg-Leu (FCIGRL-OH), a peptide...

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Main Authors: Dong-Ho Jeong, Jung-Woo Kim, Keon-Hyoung Song
Format: Artigo
Language:Inglês
Published: MDPI AG 2025-10-01
Series:Pharmaceutics
Subjects:
permeation enhancer
tight junction modulator
zonula occludens toxin
cyclosporin A
Online Access:https://www.mdpi.com/1999-4923/17/11/1395
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