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Epithelial–stromal cell interactions and extracellular matrix mechanics drive the formation of airway-mimetic tubular morphology in lung organoids

Summary: Complex human airway cellular organization where extracellular matrix (ECM) and epithelial and stromal lineages interact present challenges for organ study in vitro. Current in vitro lung models that focus on the lung epithelium do not represent complex airway morphology and cell-ECM intera...

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Ngā kaituhi matua: Tankut.G. Güney, Alfonso Muinelo Herranz, Sharon Mumby, Iain E. Dunlop, Ian M. Adcock
Hōputu: Artigo
Reo:Inglês
I whakaputaina: Elsevier 2021-09-01
Rangatū:iScience
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Urunga tuihono:http://www.sciencedirect.com/science/article/pii/S2589004221010294
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