Epigenetic reactivation of tumor suppressor genes with CRISPRa technologies as precision therapy for hepatocellular carcinoma

Abstract Background Epigenetic silencing of tumor suppressor genes (TSGs) is a key feature of oncogenesis in hepatocellular carcinoma (HCC). Liver-targeted delivery of CRISPR-activation (CRISPRa) systems makes it possible to exploit chromatin plasticity, by reprogramming transcriptional dysregulatio...

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Detalhes bibliográficos

Principais autores:	Agustin Sgro, Joseph Cursons, Charlene Waryah, Eleanor A. Woodward, Momeneh Foroutan, Ruqian Lyu, George C. T. Yeoh, Peter J. Leedman, Pilar Blancafort
Formato:	Artigo
Idioma:	Inglês
Publicado em:	BMC 2023-04-01
coleção:	Clinical Epigenetics
Assuntos:	CRISPRa Genome multiplexing Epigenetic editing toolbox Tumor suppressor genes Hepatocellular carcinoma Epigenetic drugs
Acesso em linha:	https://doi.org/10.1186/s13148-023-01482-0
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