Novel regulation mechanism of histone methyltransferase SMYD5 in rheumatoid arthritis

Abstract Background Fibroblast-like synoviocytes (FLS) are crucial for maintaining synovial homeostasis. SMYD5, a member of the histone lysine methyltransferase subfamily SMYDs, is involved in many pathological processes. This study aimed to investigate the role of SMYD5 in regulating synovial fibro...

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Autori principali:	Chenxi Xiao, Zhenghua Su, Jialin Zhao, Subei Tan, Mengting He, Yuhui Li, Jiayao Liu, Jie Xu, Yajie Hu, Zhongzheng Li, Chunxiang Fan, Xinhua Liu
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	BMC 2025-03-01
Serie:	Cellular & Molecular Biology Letters
Soggetti:	Rheumatoid arthritis Fibroblast-like synoviocytes SMYD5 FoxO1 HK2 NF-κB
Accesso online:	https://doi.org/10.1186/s11658-025-00707-9
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