Endothelial SIRT3 regulates myofibroblast metabolic shifts in diabetic kidneys

Summary: Defects in endothelial cells cause deterioration in kidney function and structure. Here, we found that endothelial SIRT3 regulates metabolic reprogramming and fibrogenesis in the kidneys of diabetic mice. By analyzing, gain of function of the SIRT3 gene by overexpression in a fibrotic mouse...

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Prif Awduron:	Swayam Prakash Srivastava, Jinpeng Li, Yuta Takagaki, Munehiro Kitada, Julie E. Goodwin, Keizo Kanasaki, Daisuke Koya
Fformat:	Artigo
Iaith:	Inglês
Cyhoeddwyd:	Elsevier 2021-05-01
Cyfres:	iScience
Pynciau:	Biological Sciences Cell Biology Functional Aspects of Cell Biology
Mynediad Ar-lein:	http://www.sciencedirect.com/science/article/pii/S2589004221003588
Tagiau:	Ychwanegu Tag Dim Tagiau, Byddwch y cyntaf i dagio'r cofnod hwn!