Efficient Intestinal Digestion and On Site Tumor‐Bioactivation are the Two Important Determinants for Chylomicron‐Mediated Lymph‐Targeting Triglyceride‐Mimetic Docetaxel Oral Prodrugs

Abstract The oral absorption of chemotherapeutical drugs is restricted by poor solubility and permeability, high first‐pass metabolism, and gastrointestinal toxicity. Intestinal lymphatic transport of lipophilic prodrugs is a promising strategy to improve the oral delivery efficiency of anticancer d...

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Detalhes bibliográficos

Principais autores:	Chutong Tian, Jingjing Guo, Gang Wang, Bingjun Sun, Kexin Na, Xuanbo Zhang, Zhuangyan Xu, Maosheng Cheng, Zhonggui He, Jin Sun
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Wiley 2019-12-01
coleção:	Advanced Science
Assuntos:	docetaxel lymph transport oral chemotherapy reduction‐sensitive triglyceride‐mimetic prodrugs
Acesso em linha:	https://doi.org/10.1002/advs.201901810
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