CD40 activation rescues antiviral CD8⁺ T cells from PD-1-mediated exhaustion.
The intrahepatic immune environment is normally biased towards tolerance. Nonetheless, effective antiviral immune responses can be induced against hepatotropic pathogens. To examine the immunological basis of this paradox we studied the ability of hepatocellularly expressed hepatitis B virus (HBV) t...
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| Главные авторы: | , , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
Public Library of Science (PLoS)
2013-01-01
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| Серии: | PLoS Pathogens |
| Online-ссылка: | http://europepmc.org/articles/PMC3708877?pdf=render |
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