Kynurenine pathway dysregulation in major depressive disorder: the convergence of excitotoxicity, neuroinflammation, and oxidative stress

Abstract Major depressive disorder (MDD) has traditionally been linked to deficient serotonergic neurotransmission, chronic stress, and heightened inflammation. Compelling evidence implicates the kynurenine pathway (KP), activated by inflammatory cytokines and stress-related signals, as a critical m...

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Autors principals:	Grace O’Regan, Zoe Plummer, Brian R Christie, Sandy R Shultz, Josh Allen
Format:	Artigo
Idioma:	Inglês
Publicat:	BMC 2026-02-01
Col·lecció:	Journal of Neuroinflammation
Matèries:	NMDA receptor Astrocytes Microglia Stress Biomarker Apoptosis
Accés en línia:	https://doi.org/10.1186/s12974-026-03717-2
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