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Kynurenine pathway dysregulation in major depressive disorder: the convergence of excitotoxicity, neuroinflammation, and oxidative stress

Abstract Major depressive disorder (MDD) has traditionally been linked to deficient serotonergic neurotransmission, chronic stress, and heightened inflammation. Compelling evidence implicates the kynurenine pathway (KP), activated by inflammatory cytokines and stress-related signals, as a critical m...

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Principais autores: Grace O’Regan, Zoe Plummer, Brian R Christie, Sandy R Shultz, Josh Allen
Format: Artigo
Sprog:Inglês
Udgivet: BMC 2026-02-01
Serier:Journal of Neuroinflammation
Fag:
NMDA receptor
Astrocytes
Microglia
Stress
Biomarker
Apoptosis
Online adgang:https://doi.org/10.1186/s12974-026-03717-2
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